3 years post-doctoral position funded by ANR (Agence Nationale de la Recherche) in a laboratory of cellular signalling (IECB/INSERM). The project is part of research program grant involving 4 laboratories. The position is immediately available and the monthly salary will be around 2300 € (based on the national scale).
Topic: Biology of endothelial cells
Theme: The project concerns the elucidation of the role of RhoGTPases in cytoskeletal remodelling with particular focus on actin-rich microdomains called podosomes and cell survival regulation in endothelial cells in response to angiogenic factors and inflammatory cytokines (notably TGFâ). The aim is to characterize further, cellular signalling alterations involved in adhesion and invasiveness and associated with physiological and pathological angiogenesis through both in vitro and in vivo approaches.
Profile: The successful candidate will be a highly motivated person, with good communication skills and a solid background in biochemistry and cell biology, and basic knowledge in molecular biology. Independently conceived projects are possible and encouraged as long as they are related to the broad topic of signal transduction. Our laboratory utilizes a multidisciplinary approach including cell biology, biochemistry, molecular biology, flow cytometry, confocal and time-lapse video microscopy, quantitative imaging and other techniques available at the IECB to investigate the molecular mechanisms of cytoskeletal dynamics.
Location: The European Institute for Chemistry and Cell Biology provides an exceptional environment and aims in the development of first class scientific programs in chemistry and biology and to favour multidisciplinary interactions (http://www.iecb. u-bordeaux. fr/). The city of Bordeaux offers an international dynamic cultural experience combined with a magnificent and sunny scenery and easy access to air travel.
Publications linked to the project:
Varon et al., Mol Cell Biol. 2006 May;26(9):3582- 94.
Moreau et al., Eur J Cell Biol. 2006 Apr;85(3-4): 319-25.
Tatin et al., J Cell Sci. 2006 Feb 15;119(Pt 4):769-81.
Moreau et al., Mol Cell Biol. 2003 Oct;23(19):6809- 22.
Further enquiries and application
Interested candidates should e-mail a letter of application, including a CV and the names and addresses of at least two referees to:
Dr Elisabeth Génot e.genot@iecb. u-bordeaux. fr Molecular and Cellular Biology
European Institute for biology and Chemistry/U441 INSERM
Molecular and Cellular Biology
2, rue robert Escarpit
33607 PESSAC CEDEX
Fax: 33 (0)5 40 00 87 26
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